Experimental research on Cu(II) porphyrin-based metal-organic frameworks used for antimicrobial photodynamic therapy

Dong-Xu Xu; Qian Duan; Hui Yu; Wenyue Dong

doi:10.1117/12.3015588

6 February 2024 Experimental research on Cu(II) porphyrin-based metal-organic frameworks used for antimicrobial photodynamic therapy

Dong-Xu Xu, Qian Duan, Hui Yu, Wenyue Dong

Author Affiliations +

Proceedings Volume 12979, Ninth International Conference on Energy Materials and Electrical Engineering (ICEMEE 2023); 129793G (2024) https://doi.org/10.1117/12.3015588
Event: 9th International Conference on Energy Materials and Electrical Engineering (ICEMEE 2023), 2023, Guilin, China

Abstract

In recent years, Antimicrobial Photodynamic Therapy (APDT) has been recognized as an attractive antimicrobial treatment option. However, even very effective photosensitizers (PSs) require high photosensitizer concentrations to kill bacteria because of the limited penetration and diffusion of PSS in the bacterial biofilm. In addition, PSs tends to aggregate and to cause self-quenching, which severely limits the therapeutic effect. In the antimicrobial experiment, a porphyrin-based Metal-Organic Framework (MOF) was synthesized, and the prepared materials were characterized by NMR hydrogen spectroscopy, UV-Vis absorption spectroscopy, and FT-IR. The bactericidal performance of the materials was evaluated by antibacterial tests, and the bactericidal effect could reach 100%. It was demonstrated that the Cu (II) porphyrin-based MOF can generate singlet oxygen in the presence of visible light, which provides a promising strategy for antimicrobial therapy.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Dong-Xu Xu, Qian Duan, Hui Yu, and Wenyue Dong "Experimental research on Cu(II) porphyrin-based metal-organic frameworks used for antimicrobial photodynamic therapy", Proc. SPIE 12979, Ninth International Conference on Energy Materials and Electrical Engineering (ICEMEE 2023), 129793G (6 February 2024); https://doi.org/10.1117/12.3015588

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available