Mechanisms of the effect of farrerol on spinal cord injury in mice: insights from bioinformatics and cell experiments

Mingjun Zhou; Jiayi Lu; Lin Shen; Chen Zhang; Hezuo Lv; Rui Wang

doi:10.1117/12.3044202

27 August 2024 Mechanisms of the effect of farrerol on spinal cord injury in mice: insights from bioinformatics and cell experiments

Mingjun Zhou, Jiayi Lu, Lin Shen, Chen Zhang, Hezuo Lv, Rui Wang

Author Affiliations +

Proceedings Volume 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024); 132520O (2024) https://doi.org/10.1117/12.3044202
Event: 2024 Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 2024, Kaifeng, China

Abstract

This study aimed to investigate the potential targets and molecular mechanisms underlying the therapeutic effects of Farrerol on spinal cord injury (SCI) using various methods. The databases TCMSP, PharmMapper, CTD, and GeneCards were utilized to collect Farrerol and SCI-related targets. Molecular docking, molecular dynamics, and cell experiments were conducted to explore the interaction between Farrerol and its target proteins. GO and KEGG pathway enrichment analyses were performed to identify the biological processes and pathways involved in Farrerol's therapeutic effects. The results showed that Farrerol significantly reduced TNF-α production in LPS-stimulated microglia, improved microglial cell apoptosis, and reduced reactive oxygen species generation. Additionally, Farrerol could decrease P65 nuclear translocation mediated by LPS, thereby suppressing the inflammatory response of microglia. The study concluded that Farrerol may improve pathological changes in spinal cord injury by inhibiting inflammation and improving cell apoptosis.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Mingjun Zhou, Jiayi Lu, Lin Shen, Chen Zhang, Hezuo Lv, and Rui Wang "Mechanisms of the effect of farrerol on spinal cord injury in mice: insights from bioinformatics and cell experiments", Proc. SPIE 13252, Fourth International Conference on Biomedicine and Bioinformatics Engineering (ICBBE 2024), 132520O (27 August 2024); https://doi.org/10.1117/12.3044202

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KEYWORDS

Spinal cord

Injuries

Proteins

Cell death

Databases

Biological research

Molecular interactions

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