Effect of spatial distribution of irradiated sites on injury selectivity in vascular tissue

Wai-Fung Cheong; Paul R. Morrison; Shawn W. Trainor; Amal K. Kurban M.D.; Oon Tian Tan M.D.

doi:10.1117/12.43936

1 June 1991 Effect of spatial distribution of irradiated sites on injury selectivity in vascular tissue

Wai-Fung Cheong, Paul R. Morrison, Shawn W. Trainor, Amal K. Kurban M.D., Oon Tian Tan M.D.

Proceedings Volume 1422, Lasers in Dermatology and Tissue Welding; (1991) https://doi.org/10.1117/12.43936
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The purpose of this study is to determine whether the extent of injury induced in blood vessels can be increased by : (a) increasing the number of sites per unit irradiation area, and (b) modifying the irradiation sequence, without compromising selectivity and specificity. Irradiation parameters comprising a wavelength of 585 nm, a pulse duration of 360 microsecond(s) , a spotsize of 3-5 mm diameter, and an energy density range of 7.0-7.5 cm-2 is applied in vivo on an albino pig. The results demonstrated that up to one third overlap of irradiated sites is tolerated without causing irreversible alteration in the epidermis and dermis. Injury remains confined predominantly to vascular tissues, and increases in severity as the sites become closer. Besides site density, the degree of injury also depends on the location of the site (center, boundary, or corner) within the irradiated matrix. These observations concur with inferences from surface temperature measurements made on an in vitro model. Another method for increasing injury is to irradiate in small clusters rather than point by point along a line.

Citation Download Citation

Wai-Fung Cheong, Paul R. Morrison, Shawn W. Trainor, Amal K. Kurban M.D., and Oon Tian Tan M.D. "Effect of spatial distribution of irradiated sites on injury selectivity in vascular tissue", Proc. SPIE 1422, Lasers in Dermatology and Tissue Welding, (1 June 1991); https://doi.org/10.1117/12.43936

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