Differential time-resolved detection of absorbance changes in composite structures

Ralph J. Nossal; Robert F. Bonner

doi:10.1117/12.44174

1 May 1991 Differential time-resolved detection of absorbance changes in composite structures

Ralph J. Nossal, Robert F. Bonner

Proceedings Volume 1431, Time-Resolved Spectroscopy and Imaging of Tissues; (1991) https://doi.org/10.1117/12.44174
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Several schemes for using time-resolved spectroscopy to determine changes in optical absorbance of a composite media are discussed. Mathematical division of measured transit-time probabilities yields a difference signal whose logarithmic decay is observable over an extended time range. This signal can be used to obtain reliable estimates of the absolute value of a change in the optical absorption of a sample. In homogeneous media, a ratio of absorbances can be determined from the ratio of the mean values of the transit-time distributions. A three optode detection system may improve the accuracy of detected absorption changes when composite media are examined.

Citation Download Citation

Ralph J. Nossal and Robert F. Bonner "Differential time-resolved detection of absorbance changes in composite structures", Proc. SPIE 1431, Time-Resolved Spectroscopy and Imaging of Tissues, (1 May 1991); https://doi.org/10.1117/12.44174

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