Light dosimetry in vivo in interstitial photodynamic therapy of human tumors

Anne Meunier Reynes; Simon Diebold; Dominique Lignon; Yves Granjon; Francois H. Guillemin

doi:10.1117/12.48214

1 November 1991 Light dosimetry in vivo in interstitial photodynamic therapy of human tumors

Anne Meunier Reynes, Simon Diebold, Dominique Lignon, Yves Granjon, Francois H. Guillemin

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48214
Event: MedTech '91, 1991, Berlin, Germany

Abstract

Photodynamic therapy, developed since 1961 with Lipson''s studies, is now limited in its clinical applications by the lack of knowledge about light comportment and the action of hematoporphyrin in tissues. Using human tumor models in mice, the intratumoral light flux was measured during an interstitial illumination (cylindrical diffusor 5 mm of length) by an argon dye laser emitting continuously at 630 nm (Spectra-Physics 375 B). The flux measured was captured by a plane-cut fiber (400 micrometers ) linked with an optical power meter (Newport 815). The light decrease in tissue had an exponential shape, and k, the global attenuation coefficient, was easily calculated as well as the depth penetration (1/k). Control measurements were performed in beef muscle, and the k value was very consistent with published data. In small tumors (3), the results presented a good reproducibility for the same histology (ksarcoma equals 0.48 +/- 0.08 mm-1, kcholangiocarcinoma equals 0.67 +/- 0.01 mm-1). The intraperitoneal injection of hematoporphyrin derivative (HpD at 10 mg/kg) did not seem to significantly influence the light evolution in tissues compared with control measurements without HpD. The simplicity and the reproducibility of this technique raises hopes of a coming clinical application and a possible comparison between different studies with measurable references.

Citation Download Citation

Anne Meunier Reynes, Simon Diebold, Dominique Lignon, Yves Granjon, and Francois H. Guillemin "Light dosimetry in vivo in interstitial photodynamic therapy of human tumors", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48214

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Photodynamic therapy

Signal attenuation

Tissues

In vivo imaging

Tumors

Light

Biomedical optics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years