Imaging cellular microtubules with the atomic-force microscope

Brenda L. Dixon Northern; Mary Ann Jordan; Leslie Wilson; Joseph A. N. Zasadzinski

doi:10.1117/12.58193

1 May 1992 Imaging cellular microtubules with the atomic-force microscope

Brenda L. Dixon Northern, Mary Ann Jordan, Leslie Wilson, Joseph A. N. Zasadzinski

Proceedings Volume 1639, Scanning Probe Microscopies; (1992) https://doi.org/10.1117/12.58193
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

We have immobilized chemically-fixed cellular microtubules and microtubule protein polymers on glow-discharged glass discs for scanning by atomic force microscopy (AFM). The images obtained by AFM resembled those obtained by conventional transmission electron microscopy of the same material. The AFM images can resolve some of the surface features of microtubules to 10 nm. Improvements in the techniques promise resolution approaching molecular dimensions.

Citation Download Citation

Brenda L. Dixon Northern, Mary Ann Jordan, Leslie Wilson, and Joseph A. N. Zasadzinski "Imaging cellular microtubules with the atomic-force microscope", Proc. SPIE 1639, Scanning Probe Microscopies, (1 May 1992); https://doi.org/10.1117/12.58193

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