Tissue welding with virus-sterilized human cryoprecipitate

Matthew R. Williams; Christian I. Fras; Richard D. Moscarelli; Steven K. Libutti M.D.; Mehmet Cengiz Oz M.D.; Lawrence S. Bass M.D.; Adrianne J. Setton; Murat Kaynar; Roman Nowygrod M.D.; Michael R. Treat M.D.

doi:10.1117/12.137351

1 June 1992 Tissue welding with virus-sterilized human cryoprecipitate

Matthew R. Williams, Christian I. Fras, Richard D. Moscarelli, Steven K. Libutti M.D., Mehmet Cengiz Oz M.D., Lawrence S. Bass M.D., Adrianne J. Setton, Murat Kaynar, Roman Nowygrod M.D., Michael R. Treat M.D.

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Proceedings Volume 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III; (1992) https://doi.org/10.1117/12.137351
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Clinical use of laser tissue soldering with cryoprecipitate has been delayed by the fear of infecting recipients with donor viral products. Solvent-Detergent (S/D) treatment of human plasma is a technique for disrupting membrane enveloped viruses and rendering them noninfectious. Dual 6 cm incisions were created on the dorsum of nine rats and closed with either standard skin staples of with laser activated S/D cryoprecipitate. The animals were sacrificed at one of three time periods: 0, 2, and 4 days. The use of the laser tissue solder significantly improved tensile strength over standard skin closures at all time periods. Deactivation of viral particles during preparation of cryoprecipitate does not reduce the utility of this material as a solder during laser bonding. Reduced infectivity of S/D prepared products enhances their clinical utility.

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Matthew R. Williams, Christian I. Fras, Richard D. Moscarelli, Steven K. Libutti M.D., Mehmet Cengiz Oz M.D., Lawrence S. Bass M.D., Adrianne J. Setton, Murat Kaynar, Roman Nowygrod M.D., and Michael R. Treat M.D. "Tissue welding with virus-sterilized human cryoprecipitate", Proc. SPIE 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III, (1 June 1992); https://doi.org/10.1117/12.137351

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KEYWORDS

Laser tissue interaction

Blood

Laser welding

Plasma

Semiconductor lasers

Skin

Tissues

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