Treatment of spontaneously occurring veterinary tumors with photodynamic therapy

Masoud Panjehpour; Alfred Legendre D.V.M.; Rick E. Sneed; Bergein F. Overholt M.D.

doi:10.1117/12.137336

1 June 1992 Treatment of spontaneously occurring veterinary tumors with photodynamic therapy

Masoud Panjehpour, Alfred Legendre D.V.M., Rick E. Sneed, Bergein F. Overholt M.D.

Proceedings Volume 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III; (1992) https://doi.org/10.1117/12.137336
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Chloroaluminum phthalocyanine tetrasulfonate was administered intravenously (1.0 mg/kg) to client owned cats and a dog with spontaneously occurring squamous cell carcinoma of head and neck. Light was delivered 48 hours post injection of the photosensitizer. An argon- pumped dye-laser was used to illuminate the lesions with 675 nm light delivered through a microlens fiber and/or a cylindrical diffuser. The light dose was 100 J/cm² superficially or 300 J/cm interstitially. Eleven photodynamic therapy treatments in seven cats and one dog were performed. Two cats received a second treatment in approximately sixty days after the initial treatment. The superficial dose of light was increased to 200 J/cm² for the second treatment. While the longest follow-up is twelve months, the responses are encouraging. The dog had a complete response. Among the cats, three showed complete response, three showed partial response and one showed no response. One cat expired two days post treatment. It is early to evaluate the response in two cats that received second treatments. Photodynamic therapy with chloroaluminum phthalocyanine tetrasulfonate was effective in treating squamous cell carcinoma in pet animals.

Citation Download Citation

Masoud Panjehpour, Alfred Legendre D.V.M., Rick E. Sneed, and Bergein F. Overholt M.D. "Treatment of spontaneously occurring veterinary tumors with photodynamic therapy", Proc. SPIE 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III, (1 June 1992); https://doi.org/10.1117/12.137336

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