Phototherapies: photosensitized inactivation of viral and protozoan infectious agents and potential application in blood banking

Millard M. Judy; James Lester Matthews; Franklin M. Sogandares-Bernal; Joseph T. Newman; Tran C. Chanh; Alain J. Marengo-Rowe

doi:10.1117/12.137515

1 June 1992 Phototherapies: photosensitized inactivation of viral and protozoan infectious agents and potential application in blood banking

Millard M. Judy, James Lester Matthews, Franklin M. Sogandares-Bernal, Joseph T. Newman, Tran C. Chanh, Alain J. Marengo-Rowe

Author Affiliations +

Proceedings Volume 1650, Medical Lasers and Systems; (1992) https://doi.org/10.1117/12.137515
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

More than 10 million units of human blood components are processed annually in the United States. Although donor screening and testing have greatly lowered the risk of transmission of viral and protozoan infectious agents, additional sterilization procedures which also preserve blood component function would be of significant value. Use of UV-A and visible-light-range photosensitizers for sterilization of blood platelets and red blood cells, respectively, is currently being aggressively investigated in laboratory-scale optical-mechanical systems. With successful demonstration of the efficacy and safety of these sterilization techniques, implementation in the blood bank setting will require scale-up to optical-mechanical systems capable of handling approximately 25,000 units daily in 500 - 1,000 blood banks in the United States.

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Millard M. Judy, James Lester Matthews, Franklin M. Sogandares-Bernal, Joseph T. Newman, Tran C. Chanh, and Alain J. Marengo-Rowe "Phototherapies: photosensitized inactivation of viral and protozoan infectious agents and potential application in blood banking", Proc. SPIE 1650, Medical Lasers and Systems, (1 June 1992); https://doi.org/10.1117/12.137515

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