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27 August 1993 Evaluation of cancer detection with whole-body positron emission tomography (PET) and 2-[F-18]fluoro-2-deoxy-D-glucose
Carl K. Hoh, Randall A. Hawkins, John A. Glaspy, Magnus Dahlbom, Nielson Y. Tse, Edward T. Hoffman, Christiaan Schiepers, Yong Choi, Sheila Rege, Egbert U. Nitzsche, Jamshid Maddahi, Michael E. Phelps
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Proceedings Volume 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods; (1993) https://doi.org/10.1117/12.151175
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States
Abstract
Until recently, positron emission tomography (PET) has been acquired and displayed in a standard transaxial image format. The development of whole body PET has allowed biochemical and physiologic imaging of the entire body, expanding the limited axial field of view of the conventional PET scanner. In this study, the application of whole body PET studies with 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) for tumor imaging was evaluated. Whole body PET studies were positive (presence of focal FDG uptake relative to surrounding tissue activity) in 61 of 70 patients (87%) with biopsy confirmed malignant tumors. PET images failed to reveal focal hypermetabolism in 9 of the 70 patients. Of the 17 patients with benign biopsies lesions, 13 patients had whole body PET studies without focal areas of FDG uptake. Because of the high glycolytic rate of malignant tissue, the whole body PET FDG technique has promise in the detection of a wide variety of both primary and metastatic malignancies. The presence of FDG uptake in benign inflammatory conditions may limit the specificity of the technique. The true positive rates for the characterization of known lesions was 87% in this series, and the PET FDG method is promising both in determining both the nature of a localized lesion, and in defining the systemic extent of malignant disease.
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Carl K. Hoh, Randall A. Hawkins, John A. Glaspy, Magnus Dahlbom, Nielson Y. Tse, Edward T. Hoffman, Christiaan Schiepers, Yong Choi, Sheila Rege, Egbert U. Nitzsche, Jamshid Maddahi, and Michael E. Phelps "Evaluation of cancer detection with whole-body positron emission tomography (PET) and 2-[F-18]fluoro-2-deoxy-D-glucose", Proc. SPIE 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods, (27 August 1993); https://doi.org/10.1117/12.151175
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KEYWORDS
Positron emission tomography
Tumors
Tissues
Biopsy
Cancer
Whole body imaging
Signal attenuation
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