Spectral characteristics of normal and atherosclerotic human coronary artery intima and media

N. Charle Morcos M.D.; Guy C. Levy; Ioana-Mihaela Rizoiu; M. Tomita

doi:10.1117/12.179922

12 July 1994 Spectral characteristics of normal and atherosclerotic human coronary artery intima and media

N. Charle Morcos M.D., Guy C. Levy, Ioana-Mihaela Rizoiu, M. Tomita

Proceedings Volume 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV; (1994) https://doi.org/10.1117/12.179922
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Efficient use and specific targeting of laser energy to atherosclerotic lesions necessitate understanding of spectral characteristics of intima and media from normal and diseased segments. We report absorption, transmission, and reflectance spectra from 19 normal and 21 diseased coronary artery segments which were obtained at autopsy within 5 to 10 h post mortem and submerged in oxygenated Ringer's solution. Spectra were obtained from the luminal surface of 1 X 1 cm full thickness arteries or bluntly dissected intima and media segments in the range 250 to 2500 nm. Water peaks were subtracted. Absorption and transmission for full thickness artery, intima, and media from normal and atherosclerotic arteries shared main bands at 1150 and 1700 nm with variation in intensity. Significant differences in reflectance showed bands at 1080, 1340, 1600, 1739 nm in normal intima and media and atherosclerotic intima but absent in media from atherosclerotic arteries. Peaks at 1340, 1600, and 1739 nm in normal intima and media are equalized in atherosclerotic intima and absent in atherosclerotic media. In conclusion, absence of reflectance at 1080, 1340, 1600, and 1739 nm in atherosclerotic media may be selectively utilized to target laser energy and ablation at intimal plaque and spare media of atherosclerotic arteries.

Citation Download Citation

N. Charle Morcos M.D., Guy C. Levy, Ioana-Mihaela Rizoiu, and M. Tomita "Spectral characteristics of normal and atherosclerotic human coronary artery intima and media", Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); https://doi.org/10.1117/12.179922

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KEYWORDS

Arteries

Reflectivity

Absorption

Laser energy

Optical spheres

Proteins

Tissues

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