Adjunctive arterial injury and photodynamic therapy with aluminium disulphonated phthalocyanine inhibits intimal hyperplasia

Isaac Nyamekye; Jean R. McEwan; Alexander J. MacRobert; Christopher C. R. Bishop; Stephen G. Bown

doi:10.1117/12.197583

23 December 1994 Adjunctive arterial injury and photodynamic therapy with aluminium disulphonated phthalocyanine inhibits intimal hyperplasia

Isaac Nyamekye, Jean R. McEwan, Alexander J. MacRobert, Christopher C. R. Bishop, Stephen G. Bown

Author Affiliations +

Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197583
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Photodynamic therapy (PDT) of proliferative vascular smooth muscle cells (SMC) reduces intimal hyperplasia (FCIH). We assess the effects of adjunctive balloon injury and immediate PDT on contractile SMC, using aluminum disulphonated phthalocyanine (AlS₂Pc) sensitization, on intimal hyperplasia. Groups of 5 Wistar rats underwent tail vein injection with 2.5 mg/kg of aluminum disulphonated phthalocyanine (AlS₂Pc). Standard carotid artery balloon injury was performed with a 2FG Fogarty embolectomy catheter and the artery irradiated with 50 J/cm². Control groups were also studied. Rats were killed at 2 and 4 weeks after treatment and perfusion fixed H&E stained cross-sections assessed by computerized morphometric measurements. Three sections per rat were analyzed. PDT treated arteries were free of FCIH formation in all cases. Laser alone (and to a lesser extent sensitizer alone) produced some reduction in the levels of FCIH compared to untreated but balloon injured vessels. The ratio of the area of intimal hyperplasia in treated vessels to the area of intimal hyperplasia in untreated (balloon only) rats were sensitizer only 98%, laser only 68% and PDT 0% at 4 weeks. PDT given at the time of angioplasty may be affective in the management of restenosis.

Citation Download Citation

Isaac Nyamekye, Jean R. McEwan, Alexander J. MacRobert, Christopher C. R. Bishop, and Stephen G. Bown "Adjunctive arterial injury and photodynamic therapy with aluminium disulphonated phthalocyanine inhibits intimal hyperplasia", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197583

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