Hyperglycemia enhances the effectiveness of PDT

Keichun Fan; Yingcai Huang; Junheng Li M.D.

doi:10.1117/12.208172

1 May 1995 Hyperglycemia enhances the effectiveness of PDT

Keichun Fan, Yingcai Huang, Junheng Li M.D.

Proceedings Volume 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV; (1995) https://doi.org/10.1117/12.208172
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

The effect of injection of 10 mg/g 50% glucose on photodynamic therapy of mouse transplantable S-180 sarcoma was studied. The concentration of hematoporphyrin monomethylether in plasma, skin, and tumor was measured by recording spectrofluorophotometer. tumor pathological section was made and necrosis area of tumor longitudinal section was measured by image processing after photoradiation of gold vapor laser. The results of this study suggested that the uptake of photosensitizer in tumor significantly increased while the uptake of photosensitizer in skin remained unchanged after glucose administration. Furthermore, glucose administration combined with PDT produced a greater tumor necrosis area than using PDT alone. The mechanisms and clinical significance were also discussed.

Citation Download Citation

Keichun Fan, Yingcai Huang, and Junheng Li M.D. "Hyperglycemia enhances the effectiveness of PDT", Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208172

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