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The protoporphyrin IX (PPIX) levels in rat liver, skin, and tumors in vivo in response to i.p. injection of delta-aminolevulinic acid were monitored by fluorescence spectroscopy. A pharmacokinetic model describes the PPIX dosimetry.
Steven L. Jacques,Tom Rodriguez, andJon A. Schwartz
"Kinetics of ALA-induced protoporphyrin IX accumulation in the liver, skin, and tumor of a rat model", Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208188
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Steven L. Jacques, Tom Rodriguez, Jon A. Schwartz, "Kinetics of ALA-induced protoporphyrin IX accumulation in the liver, skin, and tumor of a rat model," Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208188