Preliminary investigation of applications in the larynx of the 810-nm high-energy pulsed diode laser

Duncan R. Ingrams; Donald F. Perrault Jr.; Michail M. Pankratov; Stanley M. Shapshay M.D.

doi:10.1117/12.209104

12 May 1995 Preliminary investigation of applications in the larynx of the 810-nm high-energy pulsed diode laser

Duncan R. Ingrams, Donald F. Perrault Jr., Michail M. Pankratov, Stanley M. Shapshay M.D.

Proceedings Volume 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V; (1995) https://doi.org/10.1117/12.209104
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Laryngeal lesions such as papillomata can be removed with CO₂ laser but the scar that forms after repeated treatments can cause reduction in the function of the larynx. This scarring may be made worse by infection caused by interruption in the epithelial surface. It is hoped that if the vasculature of these lesions can be thrombosed without damage to the epithelium, the lesion will atrophy without the risk of infection and scar formation. A series of in vitro experiments were carried out to determine if the 810 nm high energy pulsed diode laser could be used to coagulate blood. Experiments with a laser fluence of 22 J/cm² on flowing and stationary animal and human blood in 750 micrometers diameter capillary tubes showed that single pulses caused a maximum detectable rise in temperature of 16 degree(s)C and no coagulation. Multiple pulses in slow flowing blood did generate a sustained temperature rise of 40 degree(s)C which may be enough to cause coagulation. Further in vitro and in vivo studies are underway to determine the clinical usefulness of this energy source.

Citation Download Citation

Duncan R. Ingrams, Donald F. Perrault Jr., Michail M. Pankratov, and Stanley M. Shapshay M.D. "Preliminary investigation of applications in the larynx of the 810-nm high-energy pulsed diode laser", Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); https://doi.org/10.1117/12.209104

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KEYWORDS

Blood

Semiconductor lasers

Capillaries

Temperature metrology

In vivo imaging

Tissues

In vitro testing

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