Use of fast neutrons for assessing sarcopenia by measuring body phosphorus: relevance to health and quality of life of the elderly

Joseph J. Kehayias; Hong Zhuang; Patricia L. Doherty

doi:10.1117/12.267934

27 February 1997 Use of fast neutrons for assessing sarcopenia by measuring body phosphorus: relevance to health and quality of life of the elderly

Joseph J. Kehayias, Hong Zhuang, Patricia L. Doherty

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Proceedings Volume 2867, International Conference Neutrons in Research and Industry; (1997) https://doi.org/10.1117/12.267934
Event: Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, 1996, Crete, Greece

Abstract

Sarcopenia, defined as the loss of skeletal muscle with age, may lead to frailty, fractures due to falls, and reduced immunity to disease. By understanding the causes of muscle loss with age we will be able to develop ways of maintaining functional capacity and quality of life for the elderly. Elemental Partition Analysis (EPA) is a new approach to body composition assessment. A major element of the body is measured and then, by means of other measurements, is partitioned to the contributing body compartments. We developed a model for measuring total body muscle by applying the EPA method to total body phosphorus (TBP). We measure TBP by in vivo fast neutron activation analysis using the reaction ³¹P(n,(alpha) )²⁸Al. The main contributors to TBP are bone and skeletal muscle. Adipose tissue and the liver contribute less than 3 percent. We use dual-energy x-ray absorptiometry (DXA) to evaluate the contribution of bone to TBP. COrrections are applied for the small contributions of the liver and adipose tissue to TBP to derive muscle phosphorus. The technique requires high precision measurements for both TBP and DXA. The total body radiation exposure for measuring human subjects is 0.30 mSv.

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Joseph J. Kehayias, Hong Zhuang, and Patricia L. Doherty "Use of fast neutrons for assessing sarcopenia by measuring body phosphorus: relevance to health and quality of life of the elderly", Proc. SPIE 2867, International Conference Neutrons in Research and Industry, (27 February 1997); https://doi.org/10.1117/12.267934

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KEYWORDS

Phosphorus

Bone

Tissues

Liver

Precision measurement

Dual energy x-ray absorptiometry

Head

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