In-vivo plasma-mediated ablation as a function of laser pulse width

Xinbing Liu; An-Chun Tien; Tibor Juhasz; Barbara Irish; Victor Elner M.D.; Ron M. Kurtz M.D.

doi:10.1117/12.275509

16 June 1997 In-vivo plasma-mediated ablation as a function of laser pulse width

Xinbing Liu, An-Chun Tien, Tibor Juhasz, Barbara Irish, Victor Elner M.D., Ron M. Kurtz M.D.

Proceedings Volume 2975, Laser-Tissue Interaction VIII; (1997) https://doi.org/10.1117/12.275509
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

We evaluated in vivo wound healing responses to plasma- mediated ablation in skin as a function of laser pulsewidth and energy. Experiments utilized a regeneratively amplified Ti:Sapphire laser operating at 800 nm with pulsewidths varied from 7 ns to 100 fs. Skin incisions were created in mice by tightly focusing the laser beam on the tissue surface. Incisions of equal depth were compared at time points ranging from 6 hours to 3 weeks using standard histologic methods. Incision depth was proportional to pulse energy at each pulsewidth. Fluence threshold dependence on laser pulsewidth agreed with those predicted by ex vivo testing. Histologic analysis revealed minimal adjacent tissue damage at pulsewidths less than a few picoseconds and energies near the fluence threshold. Longer pulsewidths and higher fluence levels were associated with more significant collateral effects. These in vivo results suggest collateral tissue damage and secondary effects may be minimized by controlling laser pulsewidth and energy.

Citation Download Citation

Xinbing Liu, An-Chun Tien, Tibor Juhasz, Barbara Irish, Victor Elner M.D., and Ron M. Kurtz M.D. "In-vivo plasma-mediated ablation as a function of laser pulse width", Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); https://doi.org/10.1117/12.275509

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available