Concentration, size, mean lifetime, and noise effects on image quality in luminescence optical tomography

Jenghwa Chang; Harry L. Graber; Randall Locke Barbour

doi:10.1117/12.280221

18 August 1997 Concentration, size, mean lifetime, and noise effects on image quality in luminescence optical tomography

Jenghwa Chang, Harry L. Graber, Randall Locke Barbour

Author Affiliations +

Proceedings Volume 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II; (1997) https://doi.org/10.1117/12.280221
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

The impact of background lumiphore in luminescence optical tomography is examined. To demonstrate its effects, numerical simulations were performed to calculate the diffusion-regime limiting form of forward-problem solutions for a specific test medium. Image reconstructions were performed using a CGD algorithm with a rescaling technique and positivity constraints. In addition, we develop a modification to the basic algorithm that makes use of the maximum possible concentration in order to estimate the background concentration, and show that it improves image quality when background lumiphore is present. We conclude that the usual measure of background lumiphore's effect, which is the target- to-background lumiphore concentration ratio, is not adequate to define the contribution from the background lumiphore. The reason for this is that image quality is also a function of target size and location. An alternative measure that we find superior is described. The results indicate that the improved algorithm yields better image quality for low target-to- background ratios.

Citation Download Citation

Jenghwa Chang, Harry L. Graber, and Randall Locke Barbour "Concentration, size, mean lifetime, and noise effects on image quality in luminescence optical tomography", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); https://doi.org/10.1117/12.280221

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