Avidin-biotin system for targeting delivery of photosensitizers and other cytotoxic agents into malignant tissues

Alexander P. Savitsky; Irina G. Meerovich; Joerg G. Moser; Raisa I. Yakubovskaya; Oleg L. Kaliya; Eugeny A. Lukyanets

doi:10.1117/12.297826

29 December 1997 Avidin-biotin system for targeting delivery of photosensitizers and other cytotoxic agents into malignant tissues

Alexander P. Savitsky, Irina G. Meerovich, Joerg G. Moser, Raisa I. Yakubovskaya, Oleg L. Kaliya, Eugeny A. Lukyanets

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297826
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

It is well established that the selectivity of accumulation of photosensitizer in malignant tissues determines largely the efficiency of photodynamic therapy. Existing photosensitizers have insufficient selectivity. Thus the conjugates of photosensitizers with different carriers are promising for targeting delivery into tumor. Recently the potential of the antibody-avidin-biotin system is well studied for in vivo diagnostics. In this work we suggest to use this system for targeted delivery of the polybiotinylated compounds into cancer cells. The avidin-biotin system is highly flexible from the point of view of the pharmacokinetics of uptake of photosensitizers and the pharmacodynamics of their action. This makes it possible to select optimal conditions for phototoxic action of polybiotinylated photosensitizers and some other drugs, which are derivatives of 'Photosens' and 'Teraphthal.'

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Alexander P. Savitsky, Irina G. Meerovich, Joerg G. Moser, Raisa I. Yakubovskaya, Oleg L. Kaliya, and Eugeny A. Lukyanets "Avidin-biotin system for targeting delivery of photosensitizers and other cytotoxic agents into malignant tissues", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297826

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