Paper
26 March 1998 Implantation of microfabricated immunoisolating biocapsules
Tejal A. Desai, Wen Hwa Chu, Mauro Ferrari, Guido Rasi, Paola Sinibaldi-Vallebona, Patrizia Borboni, G. Beattie, A. Hayek
Author Affiliations +
Proceedings Volume 3258, Micro- and Nanofabricated Structures and Devices for Biomedical Environmental Applications; (1998) https://doi.org/10.1117/12.304387
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States
Abstract
Silicon-based biocapsules have been microfabricated with uniform and well-controlled pore dimensions in the tens of nanometer range to provide effective immunoisolation of cell xenografts. Surface and bulk micromachining were integrated in the fabrication process, resulting in a diffusion membrane with mechanical and chemical stability, surrounded by an anisotropically-etched silicon wafer, which serves as the encapsulation cavity. The membrane allows the diffusion of essential nutrients while blocking the passage of immune molecules, which may destroy cellular transplants. Preliminary short term studies on both primary pancreatic islets and insulinoma cell lines encapsulated within microfabricated biocapsules were conducted to determine the toxicity and biocompatibility of biocapsules, the viability and functionality of encapsulated cells, as well as the overall immunoprotective capabilities of the biocapsule. Results seem to indicate that microfabricated biocapsules are non-toxic and do not elicit any adverse inflammatory reactions when implanted. Furthermore, encapsulated insulinoma cells remained viable and functional within microfabricated environments in vivo. These results show the feasibility and potential application of microfabricated biocapsules for several pathologies.
© (1998) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Tejal A. Desai, Wen Hwa Chu, Mauro Ferrari, Guido Rasi, Paola Sinibaldi-Vallebona, Patrizia Borboni, G. Beattie, and A. Hayek "Implantation of microfabricated immunoisolating biocapsules", Proc. SPIE 3258, Micro- and Nanofabricated Structures and Devices for Biomedical Environmental Applications, (26 March 1998); https://doi.org/10.1117/12.304387
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Cited by 11 scholarly publications.
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KEYWORDS
Microfabrication

Glucose

Silicon

Tissues

In vivo imaging

Blood

Natural surfaces

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