Image reconstruction of continuously varying objects and simulated breast cancer lesions

Troy O. McBride; Brian W. Pogue; Ulf L. Oesterberg; Keith D. Paulsen

doi:10.1117/12.356853

15 July 1999 Image reconstruction of continuously varying objects and simulated breast cancer lesions

Troy O. McBride, Brian W. Pogue, Ulf L. Oesterberg, Keith D. Paulsen

Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356853
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Numerical simulations of near-infrared diffusion tomography are used to reconstruct absorption and scattering images of continuously varying objects and simulated breast cancer lesions. The breast cancer lesions are modeled using chromophore levels derived from typical breast anatomy and an approximation for breast cancer lesions based on contemporary investigations of tissue/tumor optical properties. Images of hemoglobin concentration and oxygenation are derived using least squares regressions on multiple wavelength near-infrared absorption images. The simulations are performed using finite element based iterative reconstructions. The results are compared with in vivo measurements of breast cancer patients acquired using near-infrared diffusion tomography.

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Troy O. McBride, Brian W. Pogue, Ulf L. Oesterberg, and Keith D. Paulsen "Image reconstruction of continuously varying objects and simulated breast cancer lesions", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356853

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