Measurement of hippocampal volume changes in serial MRI scans

Julia Anne Schnabel; Louis Lemieux; U. C. Wieshmann; Simon Robert Arridge

doi:10.1117/12.348535

21 May 1999 Measurement of hippocampal volume changes in serial MRI scans

Julia Anne Schnabel, Louis Lemieux, U. C. Wieshmann, Simon Robert Arridge

Proceedings Volume 3661, Medical Imaging 1999: Image Processing; (1999) https://doi.org/10.1117/12.348535
Event: Medical Imaging '99, 1999, San Diego, CA, United States

Abstract

We present a new method for the detection and measurement of volume changes in human hippocampi in serial Magnetic Resonance Imaging (MRI). The method follows a two-stage approach: (1) precise co-registration and intensity matching of the initial (baseline) and follow-up scan, and (2) refinement and segmentation propagation of the hippocampi outlines drawn in the baseline scan by an expert observer to the matched scan (co-registered and intensity matched follow- up scan of the time series). The first step is performed using MRreg, a rigid registration tool based on cross-correlation and intensity matching, and the second step makes use of the concept of active contour models for tracking the hippocampi outlines in the time series.

Citation Download Citation

Julia Anne Schnabel, Louis Lemieux, U. C. Wieshmann, and Simon Robert Arridge "Measurement of hippocampal volume changes in serial MRI scans", Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); https://doi.org/10.1117/12.348535

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