Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

Jacqueline Hewett; Valerie Nadeau; James Ferguson; Harry Moseley; Sally Ibbotson; Lorenzo Brancaleon; David J. Birkin; Wilson Sibbett; Miles J. Padgett

doi:10.1117/12.424437

9 April 2001 Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

Jacqueline Hewett, Valerie Nadeau, James Ferguson, Harry Moseley, Sally Ibbotson, Lorenzo Brancaleon, David J. Birkin, Wilson Sibbett, Miles J. Padgett

Author Affiliations +

Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424437
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitiser before during and after ALA based PDT.

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Jacqueline Hewett, Valerie Nadeau, James Ferguson, Harry Moseley, Sally Ibbotson, Lorenzo Brancaleon, David J. Birkin, Wilson Sibbett, and Miles J. Padgett "Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); https://doi.org/10.1117/12.424437

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