ABT-controllable laser hyperthermia of biological objects

Eugene V. Krotov; Ivan V. Yakovlev; Maxim Zhadobov; Alexander M. Reyman

doi:10.1117/12.468332

28 May 2002 ABT-controllable laser hyperthermia of biological objects

Eugene V. Krotov, Ivan V. Yakovlev, Maxim Zhadobov, Alexander M. Reyman

Proceedings Volume 4622, Optical Diagnostics of Living Cells V; (2002) https://doi.org/10.1117/12.468332
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The results of experimentally investigated laser heating of optically absorbing inhomogeneities inside the biological objects accompanied with monitoring of internal temperature by acoustical brightness thermometry (ABT) have been presented. One of the urgent problems of modern medicine is to provide organism safety during photodynamic therapy of various neoplasms including malignant ones. In the case when neoplasm differs from normal tissue mainly in optical absorption it seems to be effective to use laser heating for this purpose. In our experiments we used the NIR emission of CW and pulse-periodic Nd:YAG lasers (1064 nm) as well as CW semiconductor laser (800 nm) for heating of tissue- simulating phantom. Optically transparent gelatine with absorbing inhomogeneity inside was used as a phantom. Internal temperature was measured non-invasively by means of multi-channel ABT after long heating of an object by laser radiation. Temperature was also measured independently by contact electronic thermometer. The results of experiments demonstrated high efficiency of ABT application for internal temperature monitoring during PDT and other hyperthermia procedures. Besides that laser radiation can be used for backlighting followed by ABT investigation of internal structure of temperature distribution inside biological tissues. This work was supported by Russian Foundation for Basic Research (Projects # 00-02-16600; 01-02-06417; 01-02- 17645) and 6th competition-expertise of young scientists of Russian Academy of Sciences (Project #399).

Citation Download Citation

Eugene V. Krotov, Ivan V. Yakovlev, Maxim Zhadobov, and Alexander M. Reyman "ABT-controllable laser hyperthermia of biological objects", Proc. SPIE 4622, Optical Diagnostics of Living Cells V, (28 May 2002); https://doi.org/10.1117/12.468332

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