Theoretical evaluation of pulsed photothermal radiometry (PPTR) for depth profiling of port wine stain skin

Bernard Choi; Boris Majaron; J. Stuart Nelson M.D.

doi:10.1117/12.476145

12 September 2003 Theoretical evaluation of pulsed photothermal radiometry (PPTR) for depth profiling of port wine stain skin

Bernard Choi, Boris Majaron, J. Stuart Nelson M.D.

Author Affiliations +

Proceedings Volume 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII; (2003) https://doi.org/10.1117/12.476145
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

The purpose of this study was to evaluate the ability of single and dual wavelength excitation pulsed photothermal radiometry (SWE- and DWE-PPTR, respectively) to profile port wine stain (PWS) skin. To this end, a numerical optical-thermal model was developed, incorporating a digitized PWS biopsy as the input skin geometry. Both SWE and DWE reconstructed depth profiles were obtained by applying an iterative, nonnegatively constrained conjugate gradient algorithm to the computed PPTR signals. The accuracy of determining the following clinically significant parameters from our reconstructions was determined: (1) average epidermal thickness (Z_epi), (2) maximum epidermal temperature rise (ΔT_epi,max), (3) initial PWS depth (Z_PWS), and (4) depth of maximum PWS temperature rise (Z_PWS,max). In the SWE-PPTR reconstruction, key parameters such as Z_epi and Z_PWS could not be determined. Comparison of the epidermal profiles of the actual and DWE-PPTR profiles revealed a good quantitative match in Z_epi and ΔT_epi,max. Comparison of the PWS profiles revealed that Z_PWS and Z_PWS,max are determined within 25% and 11%, respectively. The results of this study indicate that DWE-PPTR is a viable tool for depth profiling of PWS skin.

Citation Download Citation

Bernard Choi, Boris Majaron, and J. Stuart Nelson M.D. "Theoretical evaluation of pulsed photothermal radiometry (PPTR) for depth profiling of port wine stain skin", Proc. SPIE 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII, (12 September 2003); https://doi.org/10.1117/12.476145

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available