Application of the standard Hough transform to high-resolution MRI of human trabecular bone to predict mechanical strength

Holger F. Bohm; Christoph Rath; Roberto A. Monetti; Dirk Muller; David Newitt; Sharmila Majumdar; Ernst J. Rummeny; Thomas M. Link

doi:10.1117/12.481137

15 May 2003 Application of the standard Hough-transform to high resolution MRI of human trabecular bone to predict mechanical strength

Holger F. Bohm, Christoph Rath, Roberto A. Monetti, Dirk Muller, David Newitt, Sharmila Majumdar, Ernst J. Rummeny, Thomas M. Link

Author Affiliations +

Proceedings Volume 5032, Medical Imaging 2003: Image Processing; (2003) https://doi.org/10.1117/12.481137
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

In this study we introduce two non-linear structural measures based on the Standard Hough-Transform (SHT) that are applied to high resolution MR-images of human trabecular bone specimens in order to predict biomechanical properties. The results are compared to bone mineral density (BMD) and linear morphometric parameters. Axial MR-images (voxel-size: 117x156x300 mm3) of 33 human femoral and 10 spinal specimens are obtained using a 3D-gradient-echo-sequence. After measurement of BMD by quantitative computed tomography (QCT) all specimens are tested destructively for maximum compressive strength (MCS). The SHT is applied to the binarized and Sobel-filtered images and the peak-value (maxH) and its corresponding bin (posH) of the normalized Hough-spectrum are determined as well as linear measures (apparent bone fraction (app.BV/TV), apparent trabecular separation (app.Tb.Sp), apparent trabecular perimeter per unit area (app.Tb.Perim)). For the spinal [femoral] specimens, R² for MCS vs. maxH is 0.72 (p=0.004) [0.49 (p<0.001)], R² for MCS vs. posH is 0.56 (p=0.013) [0.55 (p<0.001)], and R2 for MCS vs. BMD is 0.43 (p=0.041) [0.72 (p<0.001)]. Correlations of the conventional, linear morphometric parameters and MCS are lower than those for the SHT-based measures or BMD, ranging from 0.20 (p=0.003) for app.BV/TV to 0.46 (p<0.001) for app.Tb.Sp. Prediction of MCS by maxH, posH, or BMD alone is improved by combination with the linear morphometric parameters in a linear regressional model (R² =0.79). In conclusion, the biomechanical strength of human trabecular bone in vitro can effectively be predicted from High-Resolution MR-images by structural measures based on SHT. In the vertebral specimens these are superior to BMD or conventional structural measures in predicting bone strength.

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Holger F. Bohm, Christoph Rath, Roberto A. Monetti, Dirk Muller, David Newitt, Sharmila Majumdar, Ernst J. Rummeny, and Thomas M. Link "Application of the standard Hough-transform to high resolution MRI of human trabecular bone to predict mechanical strength", Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); https://doi.org/10.1117/12.481137

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