Hydrophobic chalcogenide fibers for cell-based bio-optical sensors

Pierre Lucas; Mark R. Riley; Michelle A. Solis; Christophe Juncker; Jayne Collier; Dianne E. Boesewetter

doi:10.1117/12.610828

23 March 2005 Hydrophobic chalcogenide fibers for cell-based bio-optical sensors

Pierre Lucas, Mark R. Riley, Michelle A. Solis, Christophe Juncker, Jayne Collier, Dianne E. Boesewetter

Proceedings Volume 5691, Optical Fibers and Sensors for Medical Applications V; (2005) https://doi.org/10.1117/12.610828
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Chalcogenide fibers are shown to exhibit a hydrophobic surface behavior which results in detection enhancement for organic species in aqueous solutions. We use these fibers to monitor the infrared signature of human lung cells and detect the presence of toxic agents in the cell surrounding media. The signal is collected using a fiber evanescent wave spectroscopy set up with live human cells acting as a sensitizer for detection of minute quantities of toxicant. A monolayer of human alveolar epithelial cells form strong attachment at the surface of the fiber sensing zone and live in contact with the fiber while their IR spectra is collected remotely. Biochemical change in the living cells are detected during exposure to toxic agents. Variations in the spectroscopic features of the cells are observed in different spectral regions. Finally, the toxicity of Te₂As₃Se₅ fibers is investigated.

Citation Download Citation

Pierre Lucas, Mark R. Riley, Michelle A. Solis, Christophe Juncker, Jayne Collier, and Dianne E. Boesewetter "Hydrophobic chalcogenide fibers for cell-based bio-optical sensors", Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005); https://doi.org/10.1117/12.610828

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