Are motor proteins power strokers, Brownian motors or both?

Brian Geislinger; Erin Darnell; Kimberly Farris; Ryoichi Kawai

doi:10.1117/12.609464

23 May 2005 Are motor proteins power strokers, Brownian motors or both? (Invited Paper)

Brian Geislinger, Erin Darnell, Kimberly Farris, Ryoichi Kawai

Proceedings Volume 5845, Noise in Complex Systems and Stochastic Dynamics III; (2005) https://doi.org/10.1117/12.609464
Event: SPIE Third International Symposium on Fluctuations and Noise, 2005, Austin, Texas, United States

Abstract

About a decade ago Brownian motors were introduced as a possible mechanism for motor protein mobility. Since then many theoretical and experimental papers have been published on the topic. While some experiments support Brownian motor mechanisms, others are more consistent with traditional power stroke models. Taking into account recent experimental data and molecular level simulations, we have developed a stochastic model which incorporates both power stroke and Brownian motor mechanisms. Depending on parameter values, this motor works as a power stroker, a Brownian motor or a hybrid of the two. Using this model we investigate the motility of single-head myosins, two-head myosins and a group of myosins (muscle). The results are compared with some experimental data.

Citation Download Citation

Brian Geislinger, Erin Darnell, Kimberly Farris, and Ryoichi Kawai "Are motor proteins power strokers, Brownian motors or both? (Invited Paper)", Proc. SPIE 5845, Noise in Complex Systems and Stochastic Dynamics III, (23 May 2005); https://doi.org/10.1117/12.609464

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