Influence of intravascular low level He-Ne laser irradiation on iNOS, total-NOS, and ET-1 in acute spinal cord-injured rabbits

Zhenchun Yin; Yinghai Dong; Jing Zhu

doi:10.1117/12.639315

11 September 2006 Influence of intravascular low level He-Ne laser irradiation on iNOS, total-NOS, and ET-1 in acute spinal cord-injured rabbits

Zhenchun Yin, Yinghai Dong, Jing Zhu

Author Affiliations +

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 59671D (2006) https://doi.org/10.1117/12.639315
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

Objective To research the influence of intravascular low level Laser irradiation (ILLLI) on total NOS, iNOS, and ET-1 in spinal cord following acute spinal cord injury (ASCI), and discuss the protective effects of ILLLI on neurons. Methods 72 rabbits were randomly divided into 3 groups: treatment group, injury group and control group. In treatment group and injury group, after laminectomy at the level of T-13, ASCI was performed by using Allen's method with slight modification (6g×10cm) on rabbits. After injury, rabbits were treated immediately with He-Ne laser (power 5 mW, 1 hour per day for 10 days). At the day of 10^th after treatment, total-NOS, iNOS, and ET-1 in spinal cord tissues were measured. Results The expression level of total-NOS, iNOS, and ET-1 in spinal cord in injury group were significantly higher than those in control group (P<0.05), while after ILLLI the level of these index in treatment group decreased statistically significantly compared with those in injury group (P<0.05). Conclusion ILLLI can significantly decrease the expression level of total-NOS, iNOS, and ET-1 in spinal cord. It indicates that ILLLI can relieve the overexpression of total-NOS, iNOS, and ET-1, and thus can perform protective effects on neurons in the course of secondary spinal cord injury (SSCI) following ASCI

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Zhenchun Yin, Yinghai Dong, and Jing Zhu "Influence of intravascular low level He-Ne laser irradiation on iNOS, total-NOS, and ET-1 in acute spinal cord-injured rabbits", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59671D (11 September 2006); https://doi.org/10.1117/12.639315

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KEYWORDS

Spinal cord

Injuries

Indium oxide

Helium neon lasers

Neurons

Tissues

Blood

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