Pharmacology of photosensitizer in rats with metastatic breast cancer: time point determination for photodynamic therapy (PDT) treatment of vertebral metastases

Margarete K. Akens D.V.M.; Albert J. M. Yee M.D.; Lothar Lilge; Shane Burch M.D.; Cari Whyne; Brian C Wilson; Stuart K. Bisland

doi:10.1117/12.628730

3 December 2007 Pharmacology of photosensitizer in rats with metastatic breast cancer: time point determination for photodynamic therapy (PDT) treatment of vertebral metastases

Margarete K. Akens D.V.M., Albert J. M. Yee M.D., Lothar Lilge, Shane Burch M.D., Cari Whyne, Brian C Wilson, Stuart K. Bisland

Author Affiliations +

Proceedings Volume 5969, Photonic Applications in Biosensing and Imaging; 596917 (2007) https://doi.org/10.1117/12.628730
Event: Photonics North, 2005, Toronto, Canada

Abstract

Photodynamic therapy (PDT) as a non-radiative treatment has been applied successfully in various cancers. PDT may be a useful adjunct in the treatment of vertebral metastases. PDT efficacy requires the administration of a photosensitiser drug followed by subsequent drug activation by wavelength specific light. The study purpose was to establish the pharmacokinetic profiles for 2 photosensitisers, BPD-MA and 5-ALA induced PpIX, to determine the optimal drug-light interval for vertebral PDT.

Citation Download Citation

Margarete K. Akens D.V.M., Albert J. M. Yee M.D., Lothar Lilge, Shane Burch M.D., Cari Whyne, Brian C Wilson, and Stuart K. Bisland "Pharmacology of photosensitizer in rats with metastatic breast cancer: time point determination for photodynamic therapy (PDT) treatment of vertebral metastases", Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 596917 (3 December 2007); https://doi.org/10.1117/12.628730

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