Adjuvant photodynamic therapy (PDT) of the superficial bladder cancer

V. V. Sokolov; I. G. Russakov; A. A. Teplov; E. V. Filonenko; R. V. Ul'yanov; A. A. Bystrov

doi:10.1117/12.640043

7 December 2006 Adjuvant photodynamic therapy (PDT) of the superficial bladder cancer

V. V. Sokolov, I. G. Russakov, A. A. Teplov, E. V. Filonenko, R. V. Ul'yanov, A. A. Bystrov

Proceedings Volume 5973, Current Research on Laser Use in Oncology: 2000-2004; 59730B (2006) https://doi.org/10.1117/12.640043
Event: Current Research on Laser Use in Oncology: 2000-2004, 2004, Moscow, Russian Federation

Abstract

Superficial transitional cell carcinoma represents 50 to 80% of newly diagnosed bladder cancer in various countries. Transurethral resection of the urinary bladder is the standard procedure for biopsy and treatment superficial bladder cancer. However recurrence tumors after transurethral resection alone is high enough (50-90%). Intravesical chemotherapy for prophylaxis after complete transurethral resection is reducing recurrence rate about 1 5%. Adjuvant intravesical Bacillus of Calmette and Guerin (BCG) is reducing recurrence rate about 30%, but frequency side effects of this therapy is very high. Purpose of this study is appreciate efficacy adjuvant PDT with photosensitizer Photogeme (Russia) of superficial bladder cancer for prophylaxis after complete transurethral resection. The follow up was from 3 to 63 months (27 months, on average). Sixty-five patients (75.6%) showed no recurrence. For the follow up period, the recurrence was revealed in 21 (24.4%) patient, in two of them it was progressing (one case of invasive growth and one case of remote metastases). Four cases of recurrence were revealed 4 months after the surgery. In other cases, the recurrence was diagnosed from 9 to 18 months.

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V. V. Sokolov, I. G. Russakov, A. A. Teplov, E. V. Filonenko, R. V. Ul'yanov, and A. A. Bystrov "Adjuvant photodynamic therapy (PDT) of the superficial bladder cancer", Proc. SPIE 5973, Current Research on Laser Use in Oncology: 2000-2004, 59730B (7 December 2006); https://doi.org/10.1117/12.640043

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KEYWORDS

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Photodynamic therapy

Bladder cancer

Bladder

Surgery

Cancer

Laser therapeutics

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