Bladder cancer diagnosis with fluorescence-image-guided optical coherence tomography

Z. G. Wang; D. B. Durand; Howard L. Adler M.D.; Y. T. Pan

doi:10.1117/12.649117

20 February 2006 Bladder cancer diagnosis with fluorescence-image-guided optical coherence tomography

Z. G. Wang, D. B. Durand, Howard L. Adler M.D., Y. T. Pan

Proceedings Volume 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X; 60790L (2006) https://doi.org/10.1117/12.649117
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

A fluorescence-image-guided OCT (FIG-OCT) system is described, and its ability to enhance the sensitivity and specificity is examined in an animal bladder cancer model. Total 97 specimens were examined by fluorescence imaging, OCT and histological microscopy. The sensitivity and specificity of FIG-OCT is 100% and 93% respectively, compared to 79% and 53% for fluorescence imaging, while the OCT examination time has been dramatically decreased by 3~4 times. In combination of endoscopic OCT, FIG-OCT is a promising technique for effective early bladder cancer diagnosis.

Citation Download Citation

Z. G. Wang, D. B. Durand, Howard L. Adler M.D., and Y. T. Pan "Bladder cancer diagnosis with fluorescence-image-guided optical coherence tomography", Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 60790L (20 February 2006); https://doi.org/10.1117/12.649117

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