Towards a patient-specific modeling II: biomechanics of a growing aneurysm

Seungik Baek; C. Alberto Figueroa; Charles A. Taylor; Jay D. Humphrey

doi:10.1117/12.653899

13 March 2006 Towards a patient-specific modeling II: biomechanics of a growing aneurysm

Seungik Baek, C. Alberto Figueroa, Charles A. Taylor, Jay D. Humphrey

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61432C (2006) https://doi.org/10.1117/12.653899
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

Recent advances in medical imaging, computational methods, and biomechanics hold great promise for engineering-based decision making in clinical practice. Towards patient-specific modeling, however, we need to synthesize better the separate advances in computational biofluid mechanics and arterial wall mechanics. In this paper, we propose a mathematical model of growing fusiform aneurysms that is able to test multiple competing hypotheses with regard to the production, removal, and organization of intramural collagen, and thus to predict their consequences in enlargement and changes in material properties of the lesion. To apply this model to realistic cases, including fluid-solid interactions, we also need to develop a method to exploit current advances in computational biofluid mechanics. Thus, we describe a method to represent highly nonlinear and anisotropic material behaviors within a linearized constitutive equation commonly employed in fluid-structure simulations of blood flow in deformable arteries.

Citation Download Citation

Seungik Baek, C. Alberto Figueroa, Charles A. Taylor, and Jay D. Humphrey "Towards a patient-specific modeling II: biomechanics of a growing aneurysm", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61432C (13 March 2006); https://doi.org/10.1117/12.653899

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