Interferometric optical online dosimetry for selective retina treatment (SRT)

Hardo Stoehr; Lars Ptaszynski; Andreas Fritz; Ralf Brinkmann

doi:10.1117/12.728460

13 July 2007 Interferometric optical online dosimetry for selective retina treatment (SRT)

Hardo Stoehr, Lars Ptaszynski, Andreas Fritz, Ralf Brinkmann

Proceedings Volume 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III; 663219 (2007) https://doi.org/10.1117/12.728460
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Selective retina treatment (SRT) is a new laser based method to treat retinal diseases associated with disorders of the retinal pigment epithelium (RPE). Applying microsecond laser pulses tissue damage spatially confined to the retinal pigment epithelium (RPE) is achieved. The RPE cell damage is caused by transient microbubbles emerging at the strongly absorbing melanin granules inside the RPE cells. Due to the spatial confinement to the RPE the photoreceptors can be spared and vision can be maintained in the treated retinal areas. A drawback for effective clinical SRT is that the laser induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is necessary in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer operated with a laser diode at 830nm. We present current results obtained with a laser slit lamp using porcine RPE explants in vitro and complete porcine eye globes ex vivo. The RPE cell damage is determined by Calcein fluorescence viability assays. With a threshold criterium for RPE cell death derived from the measured interferometric signal transients good agreement with the results of the viability assays is achieved.

Citation Download Citation

Hardo Stoehr, Lars Ptaszynski, Andreas Fritz, and Ralf Brinkmann "Interferometric optical online dosimetry for selective retina treatment (SRT)", Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 663219 (13 July 2007); https://doi.org/10.1117/12.728460

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available