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Recently, quality factors greater than 100 million were demonstrated using planar
arrays of silica microtoroid resonators. These high Q factors allow the toroidal
resonators to perform very sensitive detection experiments. By functionalizing
the silica surface of the toroid using antibodies, the toroidal resonators become
both specific and sensitive detectors. Targeted detection of Interleukin-2, a
cytokine which stimulates production of T cells, is demonstrated. Additional
cross-reactivity experiments are also performed to verify the sensor's behavior in
a more complex environment.
Andrea M. Armani,Scott E. Fraser, andKerry J. Vahala
"Label-free detection of chemical messenger proteins", Proc. SPIE 6717, Optomechatronic Micro/Nano Devices and Components III, 67170D (15 September 2007); https://doi.org/10.1117/12.754339
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Andrea M. Armani, Scott E. Fraser, Kerry J. Vahala, "Label-free detection of chemical messenger proteins," Proc. SPIE 6717, Optomechatronic Micro/Nano Devices and Components III, 67170D (15 September 2007); https://doi.org/10.1117/12.754339