Research on fluorescence spectra of cancer blood

Kunxiang Liu; Wenliang He; Wenyan Zhao; Ying Liu

doi:10.1117/12.758771

8 January 2008 Research on fluorescence spectra of cancer blood

Kunxiang Liu, Wenliang He, Wenyan Zhao, Ying Liu

Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 68262Q (2008) https://doi.org/10.1117/12.758771
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

The fluorescence spectral characteristic of tumor blood was studied by laser-induced fluorescence technology, and compared with the fluorescence spectra of the same type healthy mice blood, the differences between them are distinct. When the whole blood solutions were induced by 407nm laser, they radiate fluorescence band from 420nm to 750 nm, which spectral peak located at 620nm. In high concentration solutions (blood concentration is higher than 4%), the fluorescence intensity are lower than normal blood, but in those low concentration solutions (blood concentration is lower than 2%) the fluorescence intensity of the tumor blood are higher than the normal ones. It is analyzed that the change of the fluorescence characteristic between the tumor blood and the normal is caused by the concentration difference of the tumor identification-porphyrin. The experimental results showed that the obvious difference of the fluorescence spectral characteristic between the forepart tumor and normal blood can offer some value assistance to clinical diagnosis on cancer.

Citation Download Citation

Kunxiang Liu, Wenliang He, Wenyan Zhao, and Ying Liu "Research on fluorescence spectra of cancer blood", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68262Q (8 January 2008); https://doi.org/10.1117/12.758771

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KEYWORDS

Luminescence

Blood

Cancer

Tumors

Diagnostics

Tissue optics

Fluorescence spectroscopy

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