Raman spectroscopy for optical diagnosis of laryngeal cancer

Seng Khoon Teh; Wei Zheng; David P. Lau M.D.; Zhiwei Huang

doi:10.1117/12.761432

8 February 2008 Raman spectroscopy for optical diagnosis of laryngeal cancer

Seng Khoon Teh, Wei Zheng, David P. Lau M.D., Zhiwei Huang

Proceedings Volume 6842, Photonic Therapeutics and Diagnostics IV; 68421S (2008) https://doi.org/10.1117/12.761432
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

In this report, the diagnostic ability of near-infrared (NIR) Raman spectroscopy for identifying the malignant tumors from normal tissues in the larynx was studied. A rapid NIR Raman system was utilized. Multivariate statistical techniques were employed to develop effective diagnostic algorithms. Raman spectra in the range of 800-1,800 cm-1 differed significantly between normal and malignant tumor tissues. The diagnostic algorithms can yielded a diagnostic sensitivity of 92.9% and specificity 83.3% for separating malignant tumors from normal laryngeal tissues. NIR Raman spectroscopy with multivariate statistical techniques has a potential for the non-invasive detection of malignant tumors in the larynx.

Citation Download Citation

Seng Khoon Teh, Wei Zheng, David P. Lau M.D., and Zhiwei Huang "Raman spectroscopy for optical diagnosis of laryngeal cancer", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68421S (8 February 2008); https://doi.org/10.1117/12.761432

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