Comparative analysis of optical absorption and optoacoustic signal generation in nanoparticles

H. Lamela; V. Cunningham; P. Pedreira; D. C. Gallego; P. Acedo; W. Fritzsche; A. Csaki; G. Festag; A. Steinbrük

doi:10.1117/12.772305

4 March 2008 Comparative analysis of optical absorption and optoacoustic signal generation in nanoparticles

H. Lamela, V. Cunningham, P. Pedreira, D. C. Gallego, P. Acedo, W. Fritzsche, A. Csaki, G. Festag, A. Steinbrük

Proceedings Volume 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 68560L (2008) https://doi.org/10.1117/12.772305
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Use of gold nanoparticles (GNPs) as a contrast agent for medical imaging is shown to improve the efficiency of optoacoustic signal generation; signal enhancement allows differentiation between different tissue types. This aspect of medical imaging is important when concerned with early cancer detection. The present paper presents a comparative analysis of two different optical techniques, optical transmission and optoacoustics, to define the different components associated with the attenuation of light in GNPs. This attenuation of light is first studied for a pure absorber where the results are shown to be in agreement for both optical methods, thus showing the effectiveness of the measurement technique. A comparative analysis is also carried out on spherical GNPs which have been synthesized to have peak absorption at the laser wavelength.

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H. Lamela, V. Cunningham, P. Pedreira, D. C. Gallego, P. Acedo, W. Fritzsche, A. Csaki, G. Festag, and A. Steinbrük "Comparative analysis of optical absorption and optoacoustic signal generation in nanoparticles", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560L (4 March 2008); https://doi.org/10.1117/12.772305

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