Oxygen saturation changes in the optic nerve head during acute intraocular pressure elevation in monkeys

Bahram Khoobehi; Hiroyuki Kawano; Jinfeng Ning; Claude F. Burgoyne; David A. Rice; Fareeha Khan; Hilary W. Thompson; James M. Beach

doi:10.1117/12.809512

18 February 2009 Oxygen saturation changes in the optic nerve head during acute intraocular pressure elevation in monkeys

Bahram Khoobehi, Hiroyuki Kawano, Jinfeng Ning, Claude F. Burgoyne, David A. Rice, Fareeha Khan, Hilary W. Thompson, James M. Beach

Author Affiliations +

Proceedings Volume 7163, Ophthalmic Technologies XIX; 716320 (2009) https://doi.org/10.1117/12.809512
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Background and Objective: To evaluate the effect of an acute elevated intraocular pressure (IOP) on oxygen saturation of structures of the optic nerve head. Study Design/Materials and Methods: In the cynomolgus monkey eye, IOP was set to 10 mm Hg, and then raised to 30, 45, and 55 mm Hg. The ONH and overlying vessels were imaged using a fundus camera attached to a hyperspectral imaging system (HSI) at 10 and 30 minutes after IOP elevation. Results: Raising IOP from 10 to 30 mm Hg did not significantly (P < 0.0001) change saturation in vessels or ONH tissue structures but at 55 mm Hg, all structures showed significant reduction. Conclusions: Quantitative assay of the blood oxygen saturation in structures on the surface and overlying the optic nerve head is possible using hyperspectral imaging techniques.

Citation Download Citation

Bahram Khoobehi, Hiroyuki Kawano, Jinfeng Ning, Claude F. Burgoyne, David A. Rice, Fareeha Khan, Hilary W. Thompson, and James M. Beach "Oxygen saturation changes in the optic nerve head during acute intraocular pressure elevation in monkeys", Proc. SPIE 7163, Ophthalmic Technologies XIX, 716320 (18 February 2009); https://doi.org/10.1117/12.809512

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