Reconstruction of fluorophore distribution for fluorescence diffuse tomography based on hybrid model

Ilya Fiks; Mikhail Kirillin; Ekaterina Sergeeva; Mikhail Kleshnin; Ilya Turchin

doi:10.1117/12.831679

9 July 2009 Reconstruction of fluorophore distribution for fluorescence diffuse tomography based on hybrid model

Ilya Fiks, Mikhail Kirillin, Ekaterina Sergeeva, Mikhail Kleshnin, Ilya Turchin

Proceedings Volume 7369, Diffuse Optical Imaging II; 73690B (2009) https://doi.org/10.1117/12.831679
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

We propose a novel method for reconstruction of fluorophore spatial distribution in a highly scattering object imaged by means of fluorescence diffuse tomography. The method is based on algebraic reconstruction principle combined with a new theoretical model of light propagation in biotissues and Monte Carlo simulations. Monte Carlo simulations are also implemented for initial data calculations in approbation of the method. The reconstruction method was tested both for simulated and experimental initial data. We demonstrate that the method provides determination of center position of fluorescent inclusion in transversal direction with the accuracy of 1 mm, in-depth direction with the accuracy of 1.5 mm and determination of size of fluorescent inclusion with the accuracy of 1.5 mm.

Citation Download Citation

Ilya Fiks, Mikhail Kirillin, Ekaterina Sergeeva, Mikhail Kleshnin, and Ilya Turchin "Reconstruction of fluorophore distribution for fluorescence diffuse tomography based on hybrid model", Proc. SPIE 7369, Diffuse Optical Imaging II, 73690B (9 July 2009); https://doi.org/10.1117/12.831679

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