Novel reflectivity-difference biosensor

Han Chen; Lian Wei; Ying Feng

doi:10.1117/12.865233

22 October 2010 Novel reflectivity-difference biosensor

Han Chen, Lian Wei, Ying Feng

Proceedings Volume 7658, 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Optoelectronic Materials and Devices for Detector, Imager, Display, and Energy Conversion Technology; 76583G (2010) https://doi.org/10.1117/12.865233
Event: 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies, 2010, Dalian, China

Abstract

The traditional immobilized biomolecule detection technique on arrays has been fluorescence, but this has limitations because of its reliance on fluorophores. Alternatively, many label-free detection techniques have been developed such as surface plasmon resonance (SPR), ellipsometry, thin-film interference, diffractometry, and waveguides. These techniques have the advantage of high speed and high sensitivity, but in exchange rely on complicated structures or detailed sensing cells. A novel reflectivity-difference biosensor is introduced in this paper. When the sensor covered with a protein layer, the cells and the land would have opposite changes of the reflectance which lead to intensity shifts at the far-field diffraction plane. Therefore, it is convenient for the operation without intricate sensor structures and multifarious optical systems.

Citation Download Citation

Han Chen, Lian Wei, and Ying Feng "Novel reflectivity-difference biosensor", Proc. SPIE 7658, 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Optoelectronic Materials and Devices for Detector, Imager, Display, and Energy Conversion Technology, 76583G (22 October 2010); https://doi.org/10.1117/12.865233

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