In utero imaging of mouse embryonic development with optical coherence tomography

Saba H. Syed; Mary E. Dickinson; Kirill V. Larin; Irina V. Larina

doi:10.1117/12.874963

11 February 2011 In utero imaging of mouse embryonic development with optical coherence tomography

Saba H. Syed, Mary E. Dickinson, Kirill V. Larin, Irina V. Larina

Proceedings Volume 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV; 78890A (2011) https://doi.org/10.1117/12.874963
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Studying progression of congenital diseases in animal models can greatly benefit from live embryonic imaging Mouse have long served as a model of mammalian embryonic developmental processes, however, due to intra-uterine nature of mammalian development live imaging is challenging. In this report we present results on live mouse embryonic imaging in utero with Optical Coherence Tomography. Embryos from 12.5 through 17.5 days post-coitus (dpc) were studied through the uterine wall. In longitudinal studies, same embryos were imaged at developmental stages 13.5, 15.5 and 17.5 dpc. This study suggests that OCT can serve as a powerful tool for live mouse embryo imaging. Potentially this technique can contribute to our understanding developmental abnormalities associated with mutations, toxic drugs.

Citation Download Citation

Saba H. Syed, Mary E. Dickinson, Kirill V. Larin, and Irina V. Larina "In utero imaging of mouse embryonic development with optical coherence tomography", Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78890A (11 February 2011); https://doi.org/10.1117/12.874963

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available