Studying skin penetration by NMR imaging

J. M. Burg; M. Voelker; P. Schlupp; T. Schmidts; U. Maeder; T. Bergmann; F. Runkel; J. T. Heverhagen; M. Fiebich

doi:10.1117/12.874886

10 February 2011 Studying skin penetration by NMR imaging

J. M. Burg, M. Voelker, P. Schlupp, T. Schmidts, U. Maeder, T. Bergmann, F. Runkel, J. T. Heverhagen, M. Fiebich

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920V (2011) https://doi.org/10.1117/12.874886
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Skin penetration studies are an important part for the development of dermal drug carrier systems. As a novel approach a 7-tesla Magnetic Resonance Imaging (MRI) Scanner was used to obtain information about the penetration of agents into the skin. The main advantage of this method is, that the properties of the skin does not influence the signals. Compared to optical assessments the MRI method is not limited to imaging depth. Furthermore, it is possible to analyze fat and water components of the skin separately. The aim of this work was to evaluate, if this method is a promising analysis tool for the visualization of the transport of substances across the skin. Gadobutrol (Gadovist^®1.0), respresenting a coventional contrast agent in MRI, was used as a model drug for the visualization of the skin penetration. These first promising results showed that Gadobutrol, incorporated in an oil-in-water emulsion, could be detected across the skin tissue compared to an aqueous solution. After 24 hours, the pixel intensity value was increased about 4-fold compared to an untreated tissue.

Citation Download Citation

J. M. Burg, M. Voelker, P. Schlupp, T. Schmidts, U. Maeder, T. Bergmann, F. Runkel, J. T. Heverhagen, and M. Fiebich "Studying skin penetration by NMR imaging", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920V (10 February 2011); https://doi.org/10.1117/12.874886

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