Studies of MRI relaxivities of gadolinium-labeled dendrons

Hongmu Pan; Marie-Christine Daniel

doi:10.1117/12.885271

26 May 2011 Studies of MRI relaxivities of gadolinium-labeled dendrons

Hongmu Pan, Marie-Christine Daniel

Proceedings Volume 8025, Smart Biomedical and Physiological Sensor Technology VIII; 80250F (2011) https://doi.org/10.1117/12.885271
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

In cancer detection, imaging techniques have a great importance in early diagnosis. The more sensitive the imaging technique and the earlier the tumor can be detected. Contrast agents have the capability to increase the sensitivity in imaging techniques such as magnetic resonance imaging (MRI). Until now, gadolinium-based contrast agents are mainly used for MRI, and show good enhancement. But improvement is needed for detection of smaller tumors at the earliest stage possible. The dendrons complexed with Gd(DOTA) were synthesized and evaluated as a new MRI contrast agent. The longitudinal and transverse relaxation effects were tested and compared with commercial drug Magnevist, Gd(DTPA).

Citation Download Citation

Hongmu Pan and Marie-Christine Daniel "Studies of MRI relaxivities of gadolinium-labeled dendrons", Proc. SPIE 8025, Smart Biomedical and Physiological Sensor Technology VIII, 80250F (26 May 2011); https://doi.org/10.1117/12.885271

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