Medical applications studies at ELI-NP

D. Habs; P. G. Thirolf; C. Lang; M. Jentschel; U. Köster; F. Negoita; V. Zamfir

doi:10.1117/12.888986

1 June 2011 Medical applications studies at ELI-NP

D. Habs, P. G. Thirolf, C. Lang, M. Jentschel, U. Köster, F. Negoita, V. Zamfir

Proceedings Volume 8079, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles; 80791H (2011) https://doi.org/10.1117/12.888986
Event: SPIE Optics + Optoelectronics, 2011, Prague, Czech Republic

Abstract

We study the production of radioisotopes for nuclear medicine in (γ, γ) photoexcitation reactions or (γ, xn+yp) photonuclear reactions for the examples of ^195mPt,^117mSn and ⁴⁴Ti with high flux [(10¹³ - 10¹⁵)γ/s], small beam diameter and small energy band width (ΔE/E ≈ 10^-3 - 10^-4) γ beams. In order to realize an optimum γ-focal spot, a refractive γ-lens consisting of a stack of many concave micro-lenses will be used. It allows for the production of a high specific activity and the use of enriched isotopes. For photonuclear reactions with a narrow γ beam, the energy deposition in the target can be reduced by using a stack of thin target wires, hence avoiding direct stopping of the Compton electrons and e⁺e^- pairs. The well-defined initial excitation energy of the compound nucleus leads to a small number of reaction channels and enables new combinations of target isotope and final radioisotope. The narrow-bandwidth γ excitation may make use of collective resonances in γ-width, leading to increased cross sections. (γ, γ) isomer production via specially selected γ cascades allows to produce high specific activity in multiple excitations, where no back-pumping of the isomer to the ground state occurs. The produced isotopes will open the way for completely new clinical applications of radioisotopes. For example ^195mPt could be used to verify the patient's response to chemotherapy with platinum compounds before a complete treatment is performed. In targeted radionuclide therapy the short-range Auger and conversion electrons of ^195mPt and ^117mSn enable a very local treatment. The generator ⁴⁴Ti allows for a PET with an additional γ-quantum (γ-PET), resulting in a reduced dose or better spatial resolution.

Citation Download Citation

D. Habs, P. G. Thirolf, C. Lang, M. Jentschel, U. Köster, F. Negoita, and V. Zamfir "Medical applications studies at ELI-NP", Proc. SPIE 8079, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles, 80791H (1 June 2011); https://doi.org/10.1117/12.888986

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