Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates

Yan Xu; Saeid Zanganeh; Innus Mohammad; Andres Aguirre; Tianheng Wang; Yi Yang; Liisa Kuhn; Michael Smith; Quing Zhu

doi:10.1117/12.2004767

25 March 2013 Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates

Yan Xu, Saeid Zanganeh, Innus Mohammad, Andres Aguirre, Tianheng Wang, Yi Yang, Liisa Kuhn, Michael Smith, Quing Zhu

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85781Z (2013) https://doi.org/10.1117/12.2004767
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this paper, we have synthesized a second generation tumor hypoxia targeted 2-nitroimidazole-ICG conjugate using piperazine linker (2-nitro-ICG-p) and validated its performance in in vivo tumor targeting. The results have shown that tumor hypoxia can be targeted with twice higher signal strength beyond three hours post-injection while the un-targeted ICG has completely washed out. The improvement of the second generation 2-nitro-ICG-p dyes is 1.2-1.3 times over the first generation 2-nitro-ICG dyes using ethanol linker beyond 3 hours post-injection which is the optimal time-window for evaluating tumor hypoxia.

Citation Download Citation

Yan Xu, Saeid Zanganeh, Innus Mohammad, Andres Aguirre, Tianheng Wang, Yi Yang, Liisa Kuhn, Michael Smith, and Quing Zhu "Target tumor hypoxia with 2-nitroimidazole-ICG dye conjugates", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781Z (25 March 2013); https://doi.org/10.1117/12.2004767

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