Simulation study of cone beam CT for visualizing cell clusters in breast biopsies

C. Laamanen; R. J. LeClair

doi:10.1117/12.2007982

6 March 2013 Simulation study of cone beam CT for visualizing cell clusters in breast biopsies

C. Laamanen, R. J. LeClair

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 86682X (2013) https://doi.org/10.1117/12.2007982
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

The feasibility of cone beam CT (CBCT) for differentiating normal epithelium from invasive carcinoma is investigated via a simulation study. The phantom consisted of a 5 mm long 5mm diameter cylinder of a 50:50 mixture of fibrous and fatty tissue. Normal epithelium and invasive carcinoma were each modeled as epithelium and connective tissue compartments with respective cross-sectional dimensions of 158 by 161 μm and 131 by 161 μm . For normal epithelium, 125 cells were placed in the compartments with a higher concentration in the basal layer. For the invasive carcinoma, 314 cells were spread out sporadically. Cells were modeled as 5.67 μm diameter spheres. The attenuation coefficients used in the simulation were those of fat for epithelium, 80:20 mixture of fibrous and fat for the connective tissue and water for cells. A point source and 50 μm detector pixels were assumed. Scatter from the phantom is negligible and was neglected. Three hundred projections were acquired at magnification 10 in vacuum using a 26 kV spectrum. The preliminary study suggest a potential application of CBCT for visualizing cell clusters. The contrast was slightly improved by using a 5 to 10 keV uniform spectrum.

Citation Download Citation

C. Laamanen and R. J. LeClair "Simulation study of cone beam CT for visualizing cell clusters in breast biopsies", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86682X (6 March 2013); https://doi.org/10.1117/12.2007982

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