In vivo two-photon imaging of climbing fibers plasticity after laser axotomy

A. L. Allegra Mascaro; P. Cesare; L. Sacconi; G. Grasselli; G. Mandolesi; B. Maco; G. W. Knott; V. De Paola; P. Strata; F. S. Pavone

doi:10.1117/12.2032180

24 June 2013 In vivo two-photon imaging of climbing fibers plasticity after laser axotomy

A. L. Allegra Mascaro, P. Cesare, L. Sacconi, G. Grasselli, G. Mandolesi, B. Maco, G. W. Knott, V. De Paola, P. Strata, F. S. Pavone

Author Affiliations +

Proceedings Volume 8804, Neurophotonics; 880407 (2013) https://doi.org/10.1117/12.2032180
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

In the adult nervous system, different neuronal classes show different regenerative behavior. Although previous studies demonstrated that olivocerebellar fibers are capable of axonal regeneration in a suitable environment as a response to injury, we have hitherto no details about the real dynamics of fiber regeneration. We set up a model of singularly axotomized climbing fibers (CF) to investigate their reparative properties in the adult central nervous system (CNS) in vivo. Here we describe the approach followed to characterize the reactive plasticity after injury.

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A. L. Allegra Mascaro, P. Cesare, L. Sacconi, G. Grasselli, G. Mandolesi, B. Maco, G. W. Knott, V. De Paola, P. Strata, and F. S. Pavone "In vivo two-photon imaging of climbing fibers plasticity after laser axotomy", Proc. SPIE 8804, Neurophotonics, 880407 (24 June 2013); https://doi.org/10.1117/12.2032180

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