AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction

Stefano Bonora; Yifan Jian; Edward N. Pugh Jr.; Marinko V. Sarunic; Robert J. Zawadzki

doi:10.1117/12.2042018

4 March 2014 AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction

Stefano Bonora, Yifan Jian, Edward N. Pugh Jr., Marinko V. Sarunic, Robert J. Zawadzki

Author Affiliations +

Proceedings Volume 8934, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII; 89340Q (2014) https://doi.org/10.1117/12.2042018
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We demonstrate Adaptive optics - Optical Coherence Tomography (OCT) with modal sensorless Adaptive Optics correction with the use of novel Adaptive Lens (AL) applied for in-vivo imaging of mouse retinas. The AL can generate low order aberrations: defocus, astigmatism, coma and spherical aberration that were used in an adaptive search algorithm. Accelerated processing of the OCT data with a Graphic Processing Unit (GPU) permitted real time extraction of image projection total intensity for arbitrarily selected retinal depth plane to be optimized. Wavefront sensorless control is a viable option for imaging biological structures for which AOOCT cannot establish a reliable wavefront that could be corrected by wavefront corrector. Image quality improvements offered by adaptive lens with sensorless AO-OCT was evaluated on in vitro samples followed by mouse retina data acquired in vivo.

Citation Download Citation

Stefano Bonora, Yifan Jian, Edward N. Pugh Jr., Marinko V. Sarunic, and Robert J. Zawadzki "AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction", Proc. SPIE 8934, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII, 89340Q (4 March 2014); https://doi.org/10.1117/12.2042018

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