Spatial resolution analysis for time-domain diffuse optical tomography based on a perturbation model

Alexander B. Konovalov; Vitaly V. Vlasov

doi:10.1117/12.2052831

30 January 2014 Spatial resolution analysis for time-domain diffuse optical tomography based on a perturbation model

Alexander B. Konovalov, Vitaly V. Vlasov

Proceedings Volume 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV; 903104 (2014) https://doi.org/10.1117/12.2052831
Event: Saratov Fall Meeting 2013, 2013, Saratov, Russian Federation

Abstract

We estimate a limit to spatial resolution in time-domain diffuse optical tomography (DOT) based on a perturbation model by Lyubimov. In the context of structure reconstruction accuracy we consider and compare three approaches to the inverse DOT problem. The first reconstructs diffuse tomograms from straight lines; the second does it from curvilinear average trajectories of photons; and the third uses the total banana-like distributions of photon trajectories. For getting estimates to resolution, we derive analytical expressions for the point spread function and the modulation transfer function, and perform a numerical experiment to reconstruct rectangular scattering objects with circular absorbing inhomogeneities. It is shown that reconstruction with photon trajectory distributions instead of straight lines gives a gain of about order of magnitude in resolution and attains the accuracy of multistep nonlinear DOT algorithms.

Citation Download Citation

Alexander B. Konovalov and Vitaly V. Vlasov "Spatial resolution analysis for time-domain diffuse optical tomography based on a perturbation model", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 903104 (30 January 2014); https://doi.org/10.1117/12.2052831

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